Protein solution shelf-life extension at accelerated conditions resulting from aggregation suppression induced by surface modified PAMAM dendrimers and other commonly used additives formulated at isotonic concentrations.

The aCgn solution was formulated in a 20 mM sodium citrate pH 5 buffer and was incubated at 52.5°C. The Con A solution was formulated in a 40 mM sodium phosphate pH 6.5 buffer and was incubated at 37°C.