Supplementary Figures and Tables

Legends for Figures Supplementary Fig 1. Gene Ontology analysis enrichment analysis for the top 32 genes with alterations in seven or more cases. Plots of -log10 (p-values) are described, and the terms with p-values less than 0.01 are shown. Supplementary Fig 2. Correlation between altered genes and metastatic sites. Plots of -log10 (p-values) versus log2 (Odds ratios) are shown. Gene names with p-values less than 0.1 are displayed. 71 patients with available metastatic data were analyzed. Fisher's exact test was used to determine the correlation between bone, liver or lung metastasis and the top 99 genes with alterations in four or more cases. Odds ratios were evaluated with Haldane-Anscombe correction, which added 0.5 to each cell count to avoid calculation errors with a cell count of zero. Supplementary Fig 3. Lollipop plots of ERBB2, ERBB3, and TP53 showing the frequency of mutations in our EMPD cohort. Oncogenic mutations are written in red letters. The number of green circles represents the number of cases with each mutation.