Structure of Mycobacterium tuberculosis InhA in complex with pyridomycin derivative KV35a (compound 12)
收藏Protein Data Bank Japan2026-02-25 更新2026-04-19 收录
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Structure of Mycobacterium tuberculosis InhA in complex with pyridomycin derivative KV35a (compound 12) Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], ~{N}-[(2~{Z},5~{R},6~{S},9~{S},10~{S},11~{R})-2-butan-2-ylidene-5,11-dimethyl-10-oxidanyl-3,7,12-tris(oxidanylidene)-9-(pyridin-3-ylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-4-chloranyl-3-oxidanyl-pyridine-2-carboxamide Authors: Publicola, G, Mourey, L, Valderrama, K, Hartkoorn, R, Maveyraud, L. Deposit date: 2025-06-12 Release date: 2026-02-11 Last modified: 2026-02-25 Method: X-RAY DIFFRACTION (1.699 Å) Cite: Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach. J.Med.Chem., 69, 2026
创建时间：
2025-06-12
