Early gene expression in salivary gland after isoproterenol treatment

Isoproterenol, a ß-adrenergic agonist, has been shown to induce salivary gland hyperplasia. To gain a better understanding of the underlying molecular changes altered by isoproterenol, microarray-based gene expression analysis was conducted on rat parotid glands at 10, 30, and 60 minutes after isoproterenol injection. After isoproterenol treatment, the number of differentially expressed genes was increased in a time-dependent manner. The regulation of up- and down-expression of genes related to cell proliferation/survival provides a better understanding of the mechanism of isoproterenol-induced parotid gland enlargement.异丙肾上腺素（Isoproterenol）作为一种β肾上腺素能受体激动剂，已被证实可诱导唾液腺增生。为深入探究异丙肾上腺素所介导的潜在分子改变，本研究对注射异丙肾上腺素后10、30及60分钟的大鼠腮腺开展了基于微阵列（microarray）的基因表达分析。经异丙肾上腺素处理后，差异表达基因（differentially expressed genes）的数量呈时间依赖性升高。对与细胞增殖/存活相关基因的上调及下调表达进行调控，有助于进一步阐明异丙肾上腺素诱导腮腺肿大的作用机制。