Transcriptome-wide expression analyses of HCT116 cell line under 5 conditions. Transcriptome-wide expression analyses of HCT116 cell line under 5 conditions

Selective regulation of target genes by transcription factors is fundamental to cell-fate determination. The tumour suppressor p53, encoded by the most frequently mutated gene in human cancer, selectively regulates subsets of target genes in response to different cues. It remains poorly understood at the genomic level and structurally how p53 target selectivity is determined by cellular factors. Here we combine transcriptomic, chromatin binding and crystallographic studies to show that p53’s genome-wide discrimination between different sets of targets is influenced by its partner iASPP. Overall design: Construct transcriptome-wide expression profiles of HCT116 cell line under 5 conditions