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Roughing up Smoothened: chemical modulators of Hedgehog signaling

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PubMed Central2002-11-06 更新2026-05-25 收录
下载链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC137068/
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资源简介:
Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified. The finding that both antagonists and agonists target the protein Smoothened supports the emerging hypothesis that Smoothened may be regulated by endogenous small molecules.
提供机构:
BMC
创建时间:
2002-11-06
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