LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)
收藏Protein Data Bank Japan2024-01-10 更新2026-03-21 收录
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https://pdbj.org/mine/summary/4uvb
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LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R) Descriptor: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate Authors: Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C. Deposit date: 2014-08-05 Release date: 2014-09-10 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C, 2014
创建时间：
2014-08-05
