Manganese (II) Activates cGAS-STING pathway

We show that Manganese (II) is a potent type I-IFN inducing agonist, stimulating cells into an anti-viral state in the absence of infection. Mechanically, Mn2+ treatment led to a profound cGAS-STING-dependent innate immune activation, conferring cells or mice viral resistance. Overall design: THP1 cells were treated with Mn2+, VACV, IFNß or empty media (control). RNA was extracted and sequenced.