Stimulation with M.tb peptide pool induces multiple signaling pathways involved in providing protection during M.tb infection. Stimulation with M.tb peptide pool induces multiple signaling pathways involved in providing protection during M.tb infection

M.tb Peptide pool induces an intricate network of signaling pathways in DCs and T cells which leads to enhanced cytokine production and T cell activation. Overall design: To understand the host changes at the transcription levels leading to an increased T cell activation and an augmented pro-inflammatory cytokine upon M.tb peptide pool treatment, we performed comparative transcriptome analysis of unstimulated dendritic cells DCs (Un-DC) vs peptide pool pulsed DCs (Pep-DC) and T cells co-cultured with unstimulated DCs (Un-TC) vs T cells co-cultured with peptide pool pulsed DCs (Pep-TC).