Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16

Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16 Descriptor: GPR61 fused to dominant negative G alpha S/I N18 chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Lees, J.A, Dias, J.M, Han, S. Deposit date: 2023-06-28 Release date: 2023-10-04 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun, 14, 2023