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Diastereoselective Ritter Reactions of Chiral Cyclic <i>N</i>-Acyliminium Ions: Synthesis of Pyrido- and Pyrrolo[2,3-<i>d</i>]oxazoles and 4-Hydroxy-5-<i>N</i>-acylaminopyrrolidines and 5-Hydroxy-6-<i>N</i>-acylaminopiperidines

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NIAID Data Ecosystem2026-03-06 收录
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Pyrido- and pyrrolo[2,3-d]oxazoles can be conveniently prepared in high yield from the Ritter reaction of nitriles and in situ generated chiral cyclic N-acyliminium ions. cis-4-Hydroxy-5-acylaminopyrrolidines and cis-5-hydroxy-6-acylaminopiperidines can be readily obtained by acid hydrolysis of these bicyclic heterocyclic compounds, respectively.

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2016-06-03
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