Peterson2010 - Integrated calcium homeostasis and bone remodelling

Peterson2010 - integrated calcium homeostasis
and bone remodelling

This model is described in the article:

A physiologically based
mathematical model of integrated calcium homeostasis and bone
remodeling.

Peterson MC, Riggs MM.
Bone 2010 Jan; 46(1): 49-63
Abstract:

Bone biology is physiologically complex and intimately
linked to calcium homeostasis. The literature provides a wealth
of qualitative and/or quantitative descriptions of cellular
mechanisms, bone dynamics, associated organ dynamics, related
disease sequela, and results of therapeutic interventions. We
present a physiologically based mathematical model of
integrated calcium homeostasis and bone biology constructed
from literature data. The model includes relevant cellular
aspects with major controlling mechanisms for bone remodeling
and calcium homeostasis and appropriately describes a broad
range of clinical and therapeutic conditions. These include
changes in plasma parathyroid hormone (PTH), calcitriol,
calcium and phosphate (PO4), and bone-remodeling markers as
manifested by hypoparathyroidism and hyperparathyroidism, renal
insufficiency, daily PTH 1-34 administration, and receptor
activator of NF-kappaB ligand (RANKL) inhibition. This model
highlights the utility of systems approaches to physiologic
modeling in the bone field. The presented bone and calcium
homeostasis model provides an integrated mathematical construct
to conduct hypothesis testing of influential system aspects, to
visualize elements of this complex endocrine system, and to
continue to build upon iteratively with the results of ongoing
scientific research.

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