Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease

This scRNA-seq dataset of five human subjects with ulcerative colitis (derived from colonic lamina propria samples), was analyzed and published as part of a larger manuscript (Mitsialis, V et al, "“Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease” in Gastroenterology), which reported immune signatures of blood and intestinal tissue differentiating ulcerative colitis from Crohn's disease from non-IBD human subjects using mass cytometry as well as scRNA-seq. scRNA-seq was performed on the lamina propria fraction of colonic intestinal tissue (obtained from diagnostic colonoscopy) of five human subjects with active ulcerative colitis. These samples were obtained during colonoscopy, cryopreserved according to the methods outlined in the aforementioned manuscript, thawed and processed for scRNA-seq. Detailed information regarding clinical metadata for each subject can be found in the supplementary files of the manuscript. Please note that raw data are not provided as they are derived from human subjects.