Transcriptomics reveals novel molecular features of SLE severity

Complex blood transcriptomes can lead to the clinical heterogeneity of systemic lupus erythematosus (SLE). In the current study, we integrated transcriptomics, public data mining and clinical parameters to reveal whether SLE severity is affected by specific genes or pathways. Overall design: Blood from SLE patients was collected and divided into two groups according to the severity of disease. Transcriptome data characteristics of the two groups were analyzed