Accessing Axially Chiral Biaryls via Organocatalytic Enantioselective Dynamic-Kinetic Resolution-Semipinacol Rearrangement

We
have developed a synthetic strategy to access axially chiral
biaryls through a dynamic-kinetic resolution-semipinacol rearrangement
process. The axial chirality together with a sp3 quaternary
carbon can be introduced in a single chemical operation. The products
can be further ring-expanded to yield biologically relevant seven-membered
dibenzolactams with inverted axial chirality.