Mutations spectra in the indicated strains.

a the following nomenclature is used: “t” and “ori” refer to the telomere and the replication origin 3006/7, respectively; “” indicate the RTS1-RFB and its polarity ( blocks replication forks moving from the telomere towards the origin 3006/7).b number of events.c event/cell/division ×10−8 ± standard error. The % of each mutation events was used to balance the rate of mutation.d value not significantly different from those for the t-ura4-ori strain (spontaneous events).