Functional MRI of emotional memory in adolescent depression: Encode.Neg gt Pos.Hits.AllSubs.GroupMean

<p>FSL5.0</p>

[](https://neurovault.org/images/14622)

### Collection description

<p>Introduction: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder. <br>Methods: Cognitive biases were investigated in 56 MDD patients aged 11-17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages. <br>Results: The neural response to encoding in adolescents with MDD was found to differ significantly from controls. Additionally, neural responses during encoding and retrieval showed differential relationships with age between patient and control groups, specifically in medial, temporal, and prefrontal regions. <br>Conclusions: These findings suggest that during adolescence neurophysiological activity associated with emotional memory differs in those with depression compared to controls and may be age sensitive. </p>

###Subject species

homo sapiens

### Map type

Other

### 数据集描述

<p>引言：重度抑郁症（MDD）是全球疾病负担的主要原因。在重度抑郁症患者中，记忆任务中的情绪一致性偏差被频繁报道，对负面刺激的记忆能力增强。迄今为止，大多数功能性磁共振成像（fMRI）研究都考察了抑郁成年人在这些偏差中的神经关联，而在青少年MDD患者中的研究较少。对青少年MDD的研究有助于更深入地理解疾病的病因和发展。 <br>方法：在56名11-17岁的MDD患者和30名匹配的健康对照组参与者中，通过自我参照的记忆任务研究了认知偏差。在编码和回忆阶段收集了行为表现和血氧水平依赖（BOLD）fMRI数据。 <br>结果：在MDD青少年中发现的神经编码反应与对照者存在显著差异。此外，编码和回忆阶段的神经反应在患者组和对照组之间表现出与年龄相关的不同关系，特别是在内侧、颞叶和前额叶区域。 <br>结论：这些发现表明，在青春期，与情绪记忆相关的神经生理活动在抑郁症患者与对照者之间存在差异，并且可能对年龄敏感。</p>

### 受试者物种

homo sapiens

### 地图类型

其他