Cell-free DNA as biomarker for sepsis by integration of microbial and host information

We report that blood cell-free DNA as a promising biomarker for the diagnosis of sepsis and for the prediction of 28-day mortality of ICU patients by integrating both human and microbial cfDNA components. Overall design: Comparison of human cfDNA fragmentation patterns and blood microbial features profiled by cfDNA between septic patients and non-septic ICU patients