Using gastric organoids to understand the role of NFκB1 in the gastric epithelium

Stomach cancer is a major health burden. A better understanding of the mechanisms underlying its development is essential for developing more effective and targeted treatments. This study aimed to use stem-cell-derived miniature mouse stomachs (known as organoids) as a novel tool to understand the role of the cancer suppressor protein NFĸB1 in keeping a healthy stomach lining. I uncovered that NFĸB1 is crucial for maintaining the morphology and integrity of healthy stomach lining whereas its loss had ripple effects on numerous other cell signalling pathways, including the abnormal activation of the WNT/β-catenin pathway that is frequently associated with stomach cancers.