UtpA and UtpB chaperone nascent pre-ribosomal RNA and the U3 snoRNP to initiate eukaryotic ribosome assembly

Early eukaryotic ribosome biogenesis involves large multi-protein complexes, which co-transcriptionally associate with pre-ribosomal RNA to form the small subunit processome早期真核生物核糖体生物发生(ribosome biogenesis)过程涉及大型多蛋白复合物(multi-protein complexes)，这类复合物可共转录结合于核糖体前体RNA(pre-ribosomal RNA)，进而形成小亚基加工体(small subunit processome)