Integrative analysis and association triangles.

Combinations of SNPs, genes and metabolites for which gene-expression explains at least a nominally significant part of the observed SNP-metabolite association. Best combination of SNP, gene and metabolite is presented in bold with corresponding statistics. Causality of expression and metabolites is determined via Mendelian Randomization. Last column shows p-values of testing whether gene-expression explains a part of the observed SNP-metabolite association (see methods section). Triangles with strongest causality per locus are show in bold.1analysed adopting Mendelian Randomisation methodIntegrative analysis and association triangles.