Catalytic Asymmetric Total Synthesis of Hedyosumins A, B, and C
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https://figshare.com/articles/dataset/Catalytic_Asymmetric_Total_Synthesis_of_Hedyosumins_A_B_and_C/3049504
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资源简介：
The
first and asymmetric total synthesis of hedyosumins A, B, and C was
accomplished in 13–14 steps from simple starting materials.
The essential tools that allow us to access the tetracyclic skeleton
include an organocatalytic [4 + 3] cycloaddition reaction, an intramolecular
aldol condensation, and an intramolecular carboxymercuration/demercuration
enabled lactonization. A CBS-catalyzed asymmetric reduction was employed
to boost the ee of the synthetic natural products to an excellent
level. This synthesis established the absolute configurations of hedyosumins
A, B, and C.
创建时间：
2016-03-14
