Sexual dimorphism in human immune system aging

We isolated peripheral blood mononuclear cells (PBMCs) from 194 community-dwelling healthy volunteers (100 women, 94 men) ages spanning adult lifespan: 56 young (ages 22-40: 23 men, 33 women), 68 middle-aged (ages 41-64: 36 men, 32 women), and 70 older subjects (65+: 35 men, 35 women). PBMCs were profiled using ATAC-seq (54 men, 66 women), RNA-seq (41 men, 34 women), and flow cytometry (62 men, 68 women). These datasets revealed immune system aging signatures in men and women and showed in which ways aging differentially affects the immune systems of men and women. A subset of these samples have been generated and analyzed previously and can be found at EGA (EGAS00001002605). This dataset on dbGaP include EGA samples as well.