Analysis of gene expression in lung adenocarcinoma cells following ectopic expression of proliferation-suppressive lncRNAs (PSLR).

RNA-sequencing was performed to gain insight into the transcriptome-wide molecular changes induced by FAM198B-AS1 (PSLR-1) or SEPTIN9-DT (PSLR-2) ectopic expression in lung adenocarcinoma cells. Following expression of PSLR-1 or PSLR-2 lncRNA or control RNA, RNA-sequencing was performed. This high-throughput data revealed elevated expression of these lncRNAs reduced the expression of genes and pathways known to induce proliferation in lung adenocarcinoma cells. Overall design: PSLR-1 or PSLR-2 expressed in lung adenocarcinoma cells and gene expression profiles were generated using RNA-sequencing.