MetaDrugSig

MetaDrugSig is a transcriptomic drug signature database containing consensus gene expression signatures for **1,009 drugs**, generated from **4,312 comparisons** across **4,013 GEO series**. Drug signatures were computed using restricted maximum likelihood (REML) random-effects meta-analysis for drugs with ≥2 independent studies (Tier 1) or edgeR differential expression for single-study drugs (Tier 2). The database covers **66,437 genes** and includes per-gene uncertainty metrics (standard error, heterogeneity estimates) not available in existing resources.