MAPT
收藏rgd.mcw.edu2025-01-15 收录
下载链接：
https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=736496
下载链接
链接失效反馈官方服务：
资源简介：
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
本基因编码微管相关蛋白tau（MAPT），其转录本经历复杂且受调控的剪接，从而产生多种mRNA类型。MAPT基因在不同神经系统的表达存在差异，这取决于神经元成熟的阶段和神经元类型。MAPT基因突变与多种神经退行性疾病相关，如阿尔茨海默病、皮克病、额颞叶痴呆、皮质基底变性以及进行性核上性麻痹。[由RefSeq提供，2008年7月]
提供机构：
Rat Genome Database
