MITF-M-dependent CDK2 expression

CDK2 is expressed in the melanocyte lineage and in melanoma cells in a manner that depends on MITF binding to E-box elements in its promoter (Du et al, 2004). CDK2 and MITF are coordinately expressed in many melanoma cell lines and CDK2 expression may contribute to the pro-proliferative effect of MITF (Du et al, 2004; Azimi et al, 2018; reviewed in Goding and Arnheiter, 2019).

CDK2基因在黑色素细胞谱系及其在黑色素瘤细胞中的表达模式，依赖于MITF蛋白与启动子区E-box元件的结合（Du et al，2004）。CDK2与MITF在众多黑色素瘤细胞系中呈协同表达，CDK2的表达可能促进MITF的促增殖效应（Du et al，2004；Azimi et al，2018；详见Goding和Arnheiter，2019年的综述）。