The TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine, which can lead to DNA demethylation. However, direct connections between TET-mediated DNA demethylation and transcriptional output
5mC is extensively remodelled during vertebrate embryo development where a single cell must give rise to myriad different cell types and tissues with diverse 5mC patterns. 5mC can be remodelled throug