Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C
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Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C Descriptor: 3-amino-1-{4-[6-chloro-8-fluoro-7-(5-methyl-1H-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... Authors: McGregor, L.M, Jenkins, M, Kerwin, C, Burke, J.E, Shokat, K.M. Deposit date: 2017-03-17 Release date: 2017-06-28 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry, 56, 2017
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2017-03-17
