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Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development

ChEBI2014-06-01 更新2026-07-21 收录

晶状体发育

细胞迁移与分化

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-49949 数据链接链接失效反馈

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Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development

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创建时间：

2014-06-01

RNA结合蛋白

晶状体发育

Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a

NIAID Data Ecosystem80

c-myc Regulates Cell Proliferation during Lens Development

晶状体发育

细胞增殖调控

Myc protooncogenes play important roles in the regulation of cell proliferation, growth, differentiation and survival during development. In various developing organs, c-myc has been shown to control

Figshare2016-01-18 更新40

N-myc regulates lens growth and terminal differentiation in vivo

晶状体发育

N-myc基因敲除转录组

We performed RNA-seq with both wild type and N-myc knock-out E14 mouse lenses and identified the differentially expressed genes affected by N-myc knockout. Overall design: We have 3 biological replica

NIAID Data Ecosystem20

Gene regulation by Pax6 in the lens placode - E9.5 (2). Mus musculus

晶状体发育

Pax6基因功能

Wild type or Pax6 fx/fx; Le-Cre-positive (Pax6-/-) surface ectoderm from E9.5 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified, pooled for each genotyp

NIAID Data Ecosystem50

Developmental expression of transcriptional regulators in αA-CLEF mice at E13.5.

晶状体发育

转录因子表达谱

Cryosections of wild-type (A, C, E, G, I, K) and αA-CLEF (B, D, F, H, J) embryos stained for DAPI (C, D), for early differentiation marker Prox1 (A, B), Sox1 (E, F), for marker of fiber cell different

Figshare2016-02-23 更新40

Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development

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