Additional file 3 of Sex specific molecular networks and key drivers of Alzheimer’s disease

Additional file 3: Supplemental Table 3. Jonckheere Trend analysis to identify genes correlated with each clinical trait and APOE genotype in each sex in the PHG of MSBB and the PFC of ROSMAP. Multiple tests were adjusted using the Benjamini–Hochberg’s FDR method. Differences in trend between males and females were assessed as well. A-B) the PHG of MSBB cohort and C-D) the PFC of ROSMAP cohort. E) Intersection among the Jonckheere based DTG signatures in the PHG of the MSBB cohort. F) Intersection of the known AD risk genes and the Jonckheere based DTG signatures in the PHG of the MSBB cohort.