Transcriptomic analysis of Pot1a/b knockout in a native mouse model of glioma

Please see the cited publication below for further details. This study found that Pot1a/b knockout in a native mouse model of glioma confers sexual dimorphism of survival and discovered sex-dependent changes in telomere content as well as signatures of immune infiltration and cell cycle in these tumors. The native mouse model of glioma used in this study (C3 model) was generated via embryonic CRISPR/Cas9 knockout of Trp53, Nf1, and Pten. Additional CRISPR/Cas9 knockout of Pot1a and Pot1b resulted in the C5 model.