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Sex-associated changes to synovial macrophages in the aging joint

NIAID Data Ecosystem2026-05-10 收录

衰老免疫学

滑膜细胞异质性

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https://www.ncbi.nlm.nih.gov/sra/SRP651177 数据链接链接失效反馈

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Single-cell analysis of aging synovial macrophage heterogeneity between sexes Overall design: CITE-seq on CD45+CD11b+Ly6g-SiglecF-Cd64+ cells isolated from hind joints of young and old, male and female mice.

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创建时间：

2026-02-13

神经损伤修复

衰老免疫学

Pro-regenerative macrophages are well known for their role in promoting tissue repair, however in aging macrophage numbers are reduced acutely and repair following nerve injury deminished. Macrophage-

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Additional file 11 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

衰老免疫学

自身免疫抗体库

Additional file 11: Table S3. Same as Table S1, but for Verification Cohort (Experiment 1116).

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Kinetical scRNAseq Analysis Reveals Immune Mechanisms Underlying Hindered Lung Recovery following Influenza Virus Infection in Aged Hosts

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Aging is a major risk factor for host morbidity and mortality upon acute respiratory virus infections. To better elucidate the immune determinants of viral pathogenesis during aging, we conducted a ti

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Gene expression of unperturbed young and aged mouse bladders. Gene expression of unperturbed young and aged mouse bladders

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膀胱组织转录组

Aging has multifaceted effects on the immune system, but how aging affects tissue-specific immunity is not well-defined. Bladder diseases characterized by chronic inflammation are highly prevalent in

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Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging II. Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging II

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To gain insight into the mechanisms by which exercise affects circulating immune cells, we subjected young and old mice to aerobic exercise and performed single cell transcriptome analysis of circulat

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Sex-associated changes to synovial macrophages in the aging joint

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