circRNA mediated drug sensitivity

In this work, we download the circRNA-drug sensitivity associations from the circRic database, in which the drug sensitivity data comes from the GDSC database, containing 80076 associations that involve 404 circRNAs and 250 drugs. Te circRic database systematically characterizes circRNAs expression profles in 935 cancer cell lines across 22 cancer lineages from Cancer Cell line Encyclopedia, and analyzed the circRNAs biogenesis regulators, the efect of circRNAs on drug response and association between circRNAs with mRNA, protein, and mutation, and predicted RNA regulatory element in circRNAs. For each individual circRNA, the Wilcoxon test is applied to identify drug sensitivity which is signifcantly associated with the circRNAs expression. Meanwhile, the association with a false discovery rate (FDR) less than 0.05 is defned as a signifcant association. In our method, only these signifcant associations are extracted as a training set which includes 4134 associations involving 271 circRNAs and 218 drugs.