Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions

ChEBI2021-04-16 更新2026-07-12 收录

受体信号通路

代谢物-受体相互作用

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-10328 数据链接链接失效反馈

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Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions

创建时间：

2021-04-16

Aorta- and liver-specific ERalpha-binding patterns and gene regulation by estrogen (ChIP-seq)

组织特异性表观遗传学

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Estrogen has vascular protective effects in premenopausal women and in women under 60 receiving hormone replacement therapy. However, estrogen also increases risks of breast and uterine cancers and of

NIAID Data Ecosystem100

Temporal transcriptional response from primary human chronic lymphocytic leukemia (CLL)-cells after B-cell receptor stimulation.

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慢性淋巴细胞白血病转录组

The B-cell receptor (BCR) signaling is crucial for the pathophysiology of most leukemias and lymphomas originated from mature B lymphocytes and has emerged as a new therapeutic target, especially for

NIAID Data Ecosystem40

GO:0004879 (nuclear receptor activity)

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生物分子网络

This network was assembled automatically by INDRA (http://indra.bio) by processing all available biomedical literature with multiple machine reading systems, and integrating curated pathway databases.

NIAID Data Ecosystem40

Analysis of estrogen-induced mRNA in endometrial cancer cells with forced expression of ER. Analysis of estrogen-induced mRNA in endometrial cancer cells with forced expression of ER

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子宫内膜癌转录组分析

We used the endometrial adenocarcinoma cell line in which the ERα cDNA gene was transfected and forcedly expressed ER. Then the factors induced by estrogen (Estradiol: E2) were measured by microarray.

NIAID Data Ecosystem50

Dietary ligands diindolylmethane and resveratrol result in diverse ERα signaling not seen after E2 and a subset of diindolylmethane mediated signaling needs concurrent AHR activation.. Dietary ligands diindolylmethane and resveratrol result in diverse ERα signaling not seen after E2 and a subset of diindolylmethane mediated signaling needs concurrent AHR activation.

乳腺癌分子机制

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Inhibitory crosstalk between estrogen receptor alpha (ER alpha ) and aryl hydrocarbon receptor (AHR) regulates 17-estradiol (E2)-dependent breast cancer cell signaling. ER alpha and AHR are transcript

NIAID Data Ecosystem40

Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions

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