To date a variety of Tissue Clearing methods have emerged as powerful tools to study intact whole organ anatomy and neuronal brain circuits. However, most of the current clearing methods are time cons
The role of tissue architecture in mediating nanoparticle transport, targeting, and biological effects is unknown due to the lack of tools for imaging nanomaterials in whole organs. Here, we developed
We present an optimized tissue clearing procedure that preserves fluorescence markers and enables immunolabeling in tissue such as mouse sciatic nerve, gut and spinal cord. By refining the original pr
