BCR-binding-properties influence the nature of the IgE response and relative IgG1 and IgE production. Mus musculus strain:BALB/c

IgE and IgG play opposing roles in the development of type 1 allergy. The findings of this paper indicate that antigen-binding properties of individual B cell receptors determine differential hypermutation rates and formation of IgE versus clonally related IgG1.