Effect of depletion of SHMT2, MTHFD2, and ALDH1L2 on gene expression of C57BL/6 primarily cultured neurons

To investigate the effects of SHMT2, MTHFD2 or ALDH1L2 on primary cultured neurons, we established primary cultured neurons with each target gene knocked down by shRNA. Comparative gene expression profiling analysis of RNA-seq data for primary cultured neurons and its KD derivatives (shSHMT2, shMTHFD2, and shALDH1L2).