Pan-Cancer Metabolism Data Explorer

Pan-Cancer Metabolism Data Explorer, is an informatic pipeline to concurrently analyze metabolomics data from over 900 tissue samples spanning seven cancer types, revealing extensive heterogeneity in metabolic changes relative to normal tissue across cancers of different tissues of origin. Despite this heterogeneity, a number of metabolites were recurrently differentially abundant across many cancers, such as lactate and acyl-carnitine species.

泛癌代谢组数据探索器（Pan-Cancer Metabolism Data Explorer）是一款生物信息学流程，可同步分析覆盖7种癌症类型的900余例组织样本的代谢组学数据，能够揭示不同组织起源的癌症中，相较于正常组织的代谢改变存在广泛异质性。尽管存在此种异质性，但仍有多种代谢物在众多癌症中反复呈现差异丰度变化，例如乳酸盐（lactate）与酰基肉碱（acyl-carnitine）类物质。

搜集汇总

背景与挑战

背景概述

Pan-Cancer Metabolism Data Explorer是一个专注于泛癌代谢分析的数据集，提供了来自7种癌症亚型、超过900个患者样本的代谢物数据，用于分析代谢物与癌症侵袭性之间的关联。该数据集整合了多种癌症类型的代谢组学数据，并支持单变量和双变量分析，以探索代谢物与临床特征（如分期）的关系，数据来源于已发表的研究和癌症基因组图谱项目。