<b>Causal association between BMI and polycystic ovarian syndrome: Bidirectional two-sample Mendelian randomization study</b>

In the study, we aim to explore the causal relationship between BMI (ukb-b-19953)and polycystic ovarian syndrome (finn-b-E4_POCS) using a bidirectional, two-sampleMR analysis with the latest GWAS database.Our results support a causal relationship in this regard. The findings highlight theimportance of recognizing and safeguarding populations at risk of PCOS due tooverweight or obesity. Inversely, our research found that the severity of PCOS mayalso be one of the potential factors contributing to BMI increase, possibly informinginnovative prevention and treatment strategies

本研究旨在借助最新全基因组关联研究（Genome-Wide Association Study，GWAS）数据库，采用双向两样本孟德尔随机化（two-sample Mendelian Randomization，two-sample MR）分析，探究身体质量指数（Body Mass Index，BMI，编号ukb-b-19953）与多囊卵巢综合征（polycystic ovarian syndrome，编号finn-b-E4_POCS）之间的因果关联。本研究结果证实了二者间存在此种因果关联，凸显了识别并保护因超重或肥胖而罹患多囊卵巢综合征风险人群的重要性。反之，本研究亦发现，多囊卵巢综合征的严重程度或可成为导致身体质量指数升高的潜在影响因素之一，该发现可为创新型多囊卵巢综合征防治策略的研发提供参考依据。