DYNLL1 targeting and local nuclear alignment in U2OS with a telomeric 12q regional pattern — reproducible data and analysis

Version 1.0.2 is a self-contained reproducible data and analysis release for the descriptive U2OS nuclear-alignment study. It consolidates the original data package and the corrected supplementary figures in one archive. All primary measurements, 335 gene/date contrasts, 88 panel-source tables, 22 supplementary tables, and the original HIF guide-level eligibility and displayed ratios are retained. Four HIF guide/replicate cells with zero denominators remain explicitly flagged. The archive provides code, complete core statistical inputs, scientific provenance, source references and reproduction reports. Bibliographic metadata are distributed as projections with nested cited-work bibliographies omitted; the U2OS Cell Map resource uses an abbreviated display title with its official DOI and source URL retained. Bulk raw JUMP images and the pretrained segmentation checkpoint are linked by public URLs and hashes. The study uses one reagent pool per gene across acquisition dates and shared controls. Independent targeting, rescue and the molecular mechanism remain unvalidated. All selected genes, dates and nonconfirming outcomes remain available. This is a data and analysis release, not a journal submission or new experimental validation. Code: https://github.com/subhajit-dutta-bio/dynll1-u2os-nuclear-alignment . Original analysis code is MIT licensed and original derived outputs are CC BY 4.0; upstream data retain their original terms as listed in THIRD_PARTY_NOTICES.txt.