UK Biobank Pharma Proteomics Project (UKB-PPP)

The UKB-PPP is a collaboration between the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma proteomic profiles of 54,219 UKB participants. As part of a collaborative analysis across the thirteen UKB-PPP partners, we conducted comprehensive protein quantitative trait loci (pQTL) mapping of 2,923 proteins that identifies 14,287 primary genetic associations, of which 85% are newly discovered, in addition to ancestry-specific pQTL mapping in non-Europeans. We identify independent secondary associations in 87% of cis and 30% of trans loci, expanding the catalogue ...UKB-PPP是英国生物库（UK Biobank, UKB）与13家生物制药公司合作开展的研究项目，旨在对54219名英国生物库参与者的血浆蛋白质组学特征进行系统表征。作为13家UKB-PPP合作方联合分析的组成部分，本研究针对2923种蛋白质开展了全面的蛋白质数量性状位点（protein quantitative trait loci, pQTL）定位分析，共鉴定出14287个主要遗传关联，其中85%为全新发现；此外还在非欧洲人群中完成了祖先特异性的pQTL定位分析。本研究同时在87%的顺式（cis）位点与30%的反式（trans）位点中鉴定出独立的次级关联，进一步扩充了相关研究目录……

搜集汇总

背景与挑战

背景概述

UK Biobank Pharma Proteomics Project (UKB-PPP)是一个大规模血浆蛋白质组学研究项目，分析了54,219名参与者的2,923种蛋白质，发现了14,287个主要遗传关联，其中85%为新发现。数据集包含人群特异性GWAS汇总统计和元数据，存储在AWS S3桶中，访问需授权。