Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha
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Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha Descriptor: (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-8-ol, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, CHLORIDE ION, ... Authors: Kiefer, J.R, Vinogradova, M, Liang, J, Wang, X, Zbieg, J, Labadie, S.S, Zhang, B, Li, J, Liang, W. Deposit date: 2019-06-20 Release date: 2019-07-17 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.203 Å) Cite: Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Bioorg.Med.Chem.Lett., 29, 2019
创建时间：
2019-06-20
