Genome Wide Association Study of Chronic TMD: Discovery Phase

The OPPERA project is investigating effects of genetic, physiological, psychological and clinical factors on the risk of developing painful temporomandibular disorder (TMD). This case-control study is a discovery-phase genome wide association study that aims to identify commonly-occurring genetic variants associated with chronic TMD. It represents the first step in a series of studies that seek to identify the genetic background of TMD. For related phenotype and targeted genotype data, please see additional studies from the OPPERA project at dbGaP phs000761).]]>
CPSQ OPPERALES OPPERAPILL OPPERARDC TMJD EXAM OPPERAPSS OPPERAQST OPPERAAPM OPPERACSQ-R OPPERAJFLS OPPERAKOHN OPPERALSL/PCL-C OPPERAMEDICAL HISTORY OPPERAOBC OPPERAParentOPPERA_23DEC14 CodebookPCS OPPERAPOMS OPPERAPSQI OPPERASPSR - BodySPSR OPPERASTAIY-1 OPPERASTAIY-2 OPPERAInclusion criteria were all three of: Age 18-44 years Planning on living in the area for the next two years Fluent in written and spoken English Exclusion criteria were any one of 13 conditions: Traumatic facial injury or surgery on the face or jaw within the six months preceding enrollment Currently receiving orthodontic treatment Pregnant or nursing Kidney failure or renal dialysis Heart disease or heart failure Chronic respiratory disease that is not controlled with medication Hypertension that is not controlled with medication Epilepsy or medication to control grand mal seizures Hyperthyroidism Diabetes that is not controlled with medication or diet Drug or alcohol abuse Psychiatric disorders or conditions that have required hospitalization Chemotherapy or radiation therapy ]]>
The OPPERA project began in 2006 with enrollment of participants into two studies at four U.S. study sites: Baltimore, MD; Buffalo, NY; Chapel Hill, NC; and Gainesville, FL. In 2012, the National Institute of Dental and Craniofacial Research (NIDCR) awarded funding to support the study for an additional five year period.]]>