Cerebrospinal fluid dynamics disorders: relationship to Alzheimer biomarkers and cognition

Objectives: To determine the frequency high-convexity tight sulci (HCTS) in a population based sample and whether the presence of HCTS and related features influenced participants’ cognitive status and classification within the new Alzheimer-biomarker framework. Methods: We analyzed 684 participants, ≥50, enrolled into the prospective population-based Mayo Clinic Study of Aging, who underwent structural MRI, amyloid PET imaging, and tau- PET imaging. A fully automated machine-learning algorithm that had been developed previously in-house was used to detect neuroimaging features of HCTS. Based on PET and MRI measures, participants were classified as having normal (A−) or abnormal (A+) amyloid, normal (T−) or abnormal (T+) tau, and normal (N−) or abnormal (N+) neurodegeneration. The neuropsychological battery assessed domain-specific and global cognitive scores. Gait speed also was assessed. Analyses were adjusted for age and sex. Results: 45/684 participants (6.6%) were classified wit...