Cryo-EM structure of CAK in complex with SY-5609

Cryo-EM structure of CAK in complex with SY-5609 Descriptor: 7-dimethylphosphoryl-3-[2-[[(3~{S})-6,6-dimethylpiperidin-3-yl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]-1~{H}-indole-6-carbonitrile, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... Authors: Feng, J, Cronin, N.B, Marineau, J.J, Greber, B.J. Deposit date: 2024-02-14 Release date: 2024-12-25 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (2.3 Å) Cite: TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network. Sci Adv, 11, 2025