Reasons for excluding mice from study (15 groups).

I, COX-2+/+, non-PC group; II, COX-2+/+, late PC group; III, COX-2−/−, non-PC group; IV, COX-2−/−, late PC group; V, B6, non-PC group; VI, B6, non-PC + vehicle group; VII, B6, non-PC + RO3244794 group; VIII, B6, late PC group; IX, B6, late PC + vehicle group; X, B6, late PC + RO3244794 group; XI, IP+/+, non-PC group; XII, IP+/+, late PC group; XIII, IP−/−, non-PC group; XIV, IP−/−, late PC group; Pilot, animals used for hemodynamic studies with RO3244794 and iloprost.