Data from: Rapid formation of non-spatial hippocampal representations consistent with behavioral timescale synaptic plasticity is modulated by entorhinal input

Behavioral timescale synaptic plasticity (BTSP) is a form of synaptic
potentiation where a single plateau potential in hippocampal neurons forms
a place field during spatial learning. However, it remains unknown whether
BTSP also forms non-spatial responses and what roles the medial and
lateral entorhinal cortex (MEC and LEC) play in driving non-spatial BTSP.
Using two-photon calcium imaging of CA1 pyramidal neurons in mice learning
an odor-cued working memory task, we observed spontaneously occurring
large plateau-like calcium events during odor cues, forming stable odor
representations. Using holographic optogenetics, we induced similar
plateau-like calcium events in single neurons that were followed by novel
odor representations. Chemogenetic inhibition of MEC reduced the frequency
of plateau-like events, whereas LEC inhibition reduced their efficiency in
forming odor representations. Together, our findings demonstrate that rare
large somatic calcium events, consistent with BTSP, precede and drive
novel odor representations in a manner differentially regulated by medial
and lateral entorhinal cortex. This dataset contains all
preprocessed data from the publication [Dorian et al 2026](Rapid formation
of non-spatial hippocampal representations consistent with behavioral
timescale synaptic plasticity is modulated by entorhinal input). All
figure panels with comparisons and statistics can be generated with the
data here and code found on GitHub, which has been written in MATLAB
version 2021a.