Supplementary Information Patra et al. (2013)

Figshare2013-11-08 更新2026-04-29 收录

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亨廷顿病分子机制

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Supplementary material to the article "A genome wide dosage suppressor network reveals genetic robustness and a novel mechanism for Huntington’s disease", by Patra et al.

创建时间：

2013-11-08

Identification of the RNA targets of RBM5 and transcriptome analysis of the brain of wild-type and R6/2 (Huntington's disease) mice

亨廷顿病分子机制

RNA结合蛋白靶点

Using the Cross-linking immuno-precipitation (CLIP) methodology combined with high throughput sequencing analysis, we have identified the RNA targets of the RNA-binding protein RBM5 in the brain of wi

NIAID Data Ecosystem90

Multi-angle light scattering (MALS) analysis of HTT1-3144 Q54 HAP401-371 samples purified from Sf9 insect cells - 2018/12/03

蛋白质生物物理学分析

亨廷顿病分子机制

Project: Biophysical investigation of purified HTT protein samples Experiment: Multi-angle light scattering (MALS) analysis of HTT1-3144 Q54 HAP401-371samples purified from Sf9 insect cells Date c

NIAID Data Ecosystem20

mRNA Sequencing of control and huntington's disease iPSC-derived medium spiny neuron-like cells and Q175 HET or WT mice. Plus and minus knockdown of PIAS1.. mRNA Sequencing of control and huntington's disease iPSC-derived medium spiny neuron-like cells and Q175 HET or WT mice. Plus and minus knockdown of PIAS1.

神经病变转录组学

亨廷顿病分子机制

HD and control patient-derived induced pluripotent stem cells were used to generate medium spiny neuron-like cells. four control in duplicate and three HD samples in duplicate with CAG repeat length i

NIAID Data Ecosystem10

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease (RNA-seq). Mus musculus

亨廷顿病分子机制

表观遗传调控

Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain.

NIAID Data Ecosystem30

Mechanism for the modifier effect of RCAN1 in neurodegeneration of Huntington's disease in patient-derived neurons [ATAC-Seq]

亨廷顿病分子机制

神经退行性靶点

Genome-wide association studies have identified Genetic Modifiers of HD (GeM-HD) comprised of polymorphic gene variants associated with accelerated or delayed onset of Huntington's disease (HD). Howev

NIAID Data Ecosystem10

Supplementary Information Patra et al. (2013)

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