PeerJ_Supplementary Materials

Alzheimer's disease (AD) is a prevalent progressive neurodegenerative human disease. Several initially highly hopeful anti-AD drugs based on the amyloid-β (Aβ) hypothesis of AD have failed recent late-phase tests, and the cause of AD remains unclear. Natural aging (AG) is a high-risk factor for AD. Here, we aim to gain insights in AD that may lead to its therapeutic treatment through conducting functional analyses of gene expression microarray data from AG and AD-affected brain. These may add to our understanding of AD pathology.